KMID : 0869220210250020065
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Journal of Korean Geriatric Psychiatry 2021 Volume.25 No. 2 p.65 ~ p.69
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A Short Review of Delirium in Patients With COVID-19
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Han Myeong-Il
Kim Yong Kim Choel-Eung Choi Mal-Rye
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Abstract
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We reviewed the clinical features, prevalence, pathophysiology, and prevention and treatment of delirium in patients with coronavirus disease of 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, has neurotropic properties, and can penetrate the central nervous system and affect brain neurons. These characteristics may explain the fact that COVID-19 patients may be particularly susceptible to delirium. COVID-19 delirium occurred more frequently in intensive care unit and emergency room settings. Patients with neurologic disorders and the elderly were more vulnerable to delirium. Clinical symptoms of COVID-19 delirium may manifest as a hyper/hypoactive type. Prevention and treatment appear to be similar to conventional treatment strategies. And the patient¡¯s feeling of isolation due to social distancing and a highly intensive labor force of medical personnel must be overcome. Melatonin, alpha-2 agonist, antipsychotics, and valproic acid have been recommended for the treatment of delirium symptoms. However, this article did not go through a systematic literature review.
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KEYWORD
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Delirium, COVID-19, SARS-CoV-2, Aged, Confusion
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